- Ramon, a pathologist, and his wife Rosario Fernandez Sison, a pediatrician, are both practicing physicians.
- Their three children (and their spouses) are all physicians: Renato Fernandez Sison, psychiatrist - his wife Luz Besa Sison, pediatrician; Reuven Fernandez Sison and his wife Pauline Jose Sison both Family Medicine practitioners; Rebecca Fernandez Sison and her husband Steven Schwartz both in Ophthalmology.
- Is also a practicing physician.
- One unusual instrument he likes to play is the "Theremin", the father of all electronic musical instruments.
- Retired from medical practice. Still working in films and television. (October 2001)
- Ramon is a history buff, a member of the Philippine History Group of Los Angeles, California, and has authored and painted all illustrations of a book about his birthplace, "Cabugao", dating back to pre-Spanish colonial times. He comes from a family prominent in Philippine politics since the late 19th century. His younger brother, Jose Maria "Joma" C. Sison, is an internationally known poet and the founding chairman of the Communist Party of the Philippines (CPP) and the New People's Army(NPA).
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