- Daughter of writer Neil Simon and Joan Baim.
- Sister of Ellen Simon.
- She and Woody Harrelson were married in Tijuana, Mexico.
- Ex-stepdaughter of Marsha Mason and Diane Lander.
- Ex-daughter-in-law of Charles Harrelson.
- Ex-sister-in-law of Brett Harrelson and Jordan Harrelson.
- Stepdaughter of Elaine Joyce.
- Niece of Danny Simon.
- Nancy and sister Ellen Simon are married to brothers: Nancy's husband is David Florimbi and Ellen's husband is Michael Florimbi. Both couples have been married since 1992.
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