John Goodman and James Pickens Jr. in Roseanne (1988)

Patrick Dempsey, James Pickens Jr., and T.R. Knight in Grey's Anatomy (2005)

James Pickens Jr. in Grey's Anatomy (2005)

James Pickens Jr., Chandra Wilson, and Branden Silverman in Grey's Anatomy (2005)

Nicole Rubio and James Pickens Jr. in Grey's Anatomy (2005)

Kevin McKidd, James Pickens Jr., and Caterina Scorsone in Grey's Anatomy (2005)

Martin Henderson and James Pickens Jr. in Grey's Anatomy (2005)

James Pickens Jr., Jerrika Hinton, and Giacomo Gianniotti in Grey's Anatomy (2005)

James Pickens Jr., Jerrika Hinton, Tom Larochelle, Peyton McDavitt, and Darby Camp in Grey's Anatomy (2005)

Debbie Allen, James Pickens Jr., Jerrika Hinton, Tom Larochelle, Peyton McDavitt, and Darby Camp in Grey's Anatomy (2005)

James Pickens Jr., Caterina Scorsone, and Apollo Garza in Grey's Anatomy (2005)

Sandra Oh, James Pickens Jr., Sara Ramirez, and Scott Garfield in Grey's Anatomy (2005)

James Pickens Jr. in The Uninvited (1996)

Debbie Allen and James Pickens Jr. in Grey's Anatomy (2005)

Patrick Dempsey, Justin Chambers, Kevin McKidd, James Pickens Jr., Ellen Pompeo, Sara Ramirez, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

Justin Chambers, James Pickens Jr., Ellen Pompeo, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Kate Walsh, Justin Chambers, Eric Dane, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)