- Was often cast as stereotypical Jewish mothers, something that always amused the devoutly Catholic Medford.
- Was nominated for Broadway's 1964 Tony Award as Best Supporting or Featured Actress (Musical) for "Funny Girl," a part she recreated in an Oscar-nominated performance in the film version of the same name, Funny Girl (1968).
- Said that her first job as a performer was holding a fishbowl for a vaudeville magician.
- She has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: A Face in the Crowd (1957) and Funny Girl (1968).
- Is one of 26 actresses to have received an Academy Award nomination for their performance in a musical; hers being Funny Girl (1968). The others, in chronological order, are: Bessie Love (The Broadway Melody (1929)), Grace Moore (One Night of Love (1934)), Jean Hagen (Singin' in the Rain (1952)), Marjorie Rambeau (Torch Song (1953)), Dorothy Dandridge (Carmen Jones (1954)), Deborah Kerr (The King and I (1956)), Rita Moreno (West Side Story (1961)), Gladys Cooper (My Fair Lady (1964)), Julie Andrews (Mary Poppins (1964), The Sound of Music (1965), and Victor/Victoria (1982)), Debbie Reynolds (The Unsinkable Molly Brown (1964)), Peggy Wood (The Sound of Music (1965)), Carol Channing (Thoroughly Modern Millie (1967)), Barbra Streisand (Funny Girl (1968)), Liza Minnelli (Cabaret (1972)), Ronee Blakley (Nashville (1975)), Lily Tomlin (Nashville (1975)), Ann-Margret (Tommy (1975)), Lesley Ann Warren (Victor/Victoria (1982)), Amy Irving (Yentl (1983)), Nicole Kidman (Moulin Rouge! (2001)), Queen Latifah (Chicago (2002)), Catherine Zeta-Jones (Chicago (2002)), Renée Zellweger (Chicago (2002)), Jennifer Hudson (Dreamgirls (2006)), Penélope Cruz (Nine (2009)), Anne Hathaway (Les Misérables (2012)), and Meryl Streep (Into the Woods (2014)).
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