- In a late 1980s interview with a Dutch youth magazine, he said that actress Cree Summer was his true love.
- Son of Bethann Hardison, a former model who now has her own modeling agency
- Went to Junior High School 104 in New York City with fellow actors Robert Downey Jr., Jon Cryer and Erica Gimpel.
- Is very famous in The Netherlands because of his character in A Different World (1987). The Dutch know exactly what is meant by "Dwayne Wayne glasses" since everyone wanted them back in the '90s.
- Has a daughter: Sophia Hardison (b. September 27, 1996) with ex-wife, Chanté Moore.
- Was mentioned in the thank you of A Different World (1987) co-star Cree Summer's 1999 debut album "Street Faerie".
- Friends with Darryl M. Bell.
- Former son-in-law of Larry Moore.
- Former brother-in-law of LaTendre' Moore.
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