- Is a singer-songwriter.
- Scott released a self-titled album in 1989, produced by singer Richard Carpenter (of The Carpenters).
- Once considered a career as a professional hockey player. Scott now plays only the position of center in benefit celebrity events.
- Scott was discovered by radio news jock Dave Maynard, who hosted Community Auditions, a local Boston-based talent show. Scott won first place because of his exceptional singing ability and came back to visit the show after he made the movie It Came Upon the Midnight Clear (1984).
- When he was just a 12-year-old taking music lessons and growing up in Massachusetts, he was selected to appear on Broadway in the musical "Nine" with Raul Julia.
- Supports the USO, American Cancer Society, and the AIDS Research Foundation.
- He got the part on ER (1994) because he auditioned for a three-episode arc and then was kept on. On ER, he was also reunited with fellow Band of Brothers (2001) cast member, Eion Bailey (Pvt. David Webster).
- Fronted the band Scott Grimes and the Misdemeanors.
- Was signed for 16 of the 22 episodes of the 2003-2004 season of ER (1994), and was a series regular during the 2005-2006 season.
- Was a guest vocalist on an album of the group 30-Odd-Foot of Grunts (the band fronted by his Mystery, Alaska (1999) co-star Russell Crowe).
- Is of Irish heritage.
- Father of actress Madison Grimes (b. 2 April 1999).
- Mother: Pam Grimes. Father: Rick Grimes.
- Scott doesn't have HBO at his home, so he had to watch Band of Brothers (2001) at his mother's house.
- Shares a birthday with Tom Hanks, one of his idols.
- An avid sports player, he plays hockey and basketball (among others).
- Welcomed second child, son Jackson Richard. (September 4, 2001)
- Niece is actress Camryn Grimes.
- Brother of actress Heather Grimes.
- Grimes and his first wife Dawn had their first child, a daughter, Madison Grimes, in April 1999.
- His CD, titled 'Livin' On The Run', was released on 22 February 2005. (2005)
- Shannen Doherty and Alyssa Milano were former co-stars of his who went on to play witches on Charmed (1998). Robin Tunney and Neve Campbell, also former co-stars, played witches in the The Craft (1996).
- Born on the same day as pool player Jeanette Lee (aka the Black Widow).
- Born at 3:11 PM EDT.
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