- Father of actor Emilio Ghione Jr..
- Emilio Ghione was hospitalised following tuberculosis in 1927. A public appeal was opened for Ghione, and the money was used to help his recovery and send him to Paris in search of work. During his stay in Paris in 1929, Ghione slept rough and his health deteriorated. He was hospitalised in Paris and Lina Cavalieri paid to send him back to Turin by train.
- Ghione directed his first film as actor-director, Il Circolo Nero, in 1913.
- In 1926, Ghione launched a theatrical revue with Kally Sambucini and Alberto Collo and toured Italy performing sketches based on the Za La Mort films.
- He was the son of a minor painter, Celestino Ghione, and initially worked as a painter of miniatures.
- Ghione led a famously decadent life, following the trends set by poet Gabriele D'Annunzio. Ghione spent a lot of money on restaurants, generous tips, clothes and antiques.
- Ghione directed, wrote, and acted in every genre of film, and directed some of the most famous stars of the time, including Francesca Bertini, Lina Cavalieri, Alberto Collo, and Hesperia.
- In 1979, a retrospective of Ghione's films was held at the Venice Film Festival.
- Ghione wrote three novels based around his Za La Mort character, an autobiography, and an essay on Italian Silent Cinema, before his death from tuberculosis in 1930.
- He began to play secondary roles in a variety of films, including the comedies of André Deed. Frustrated by the slow progress of his career, Ghione left Turin in 1911 to seek his fortune in Rome.
- Ghione's decadent lifestyle and expensive habits left him nearly penniless when the Italian film industry collapsed in 1922. In 1923, he left for Germany to make Zalamort - Der Traum der Zalavie with Fern Andra, but the film was a commercial failure, owing partially to the fact that it was extensively cut by the censors.
- In Rome, Ghione quickly progressed to starring roles in films made by Cines and Celio-Film, such as Il poverello di assisi (St Francis on its British release). Ghione then starred in a series of films alongside Francesca Bertini and Alberto Collo, including Histoire d'un Pierrot.
- Ghione secured work in Turin's growing film industry in 1908, initially as a set-hand and stuntman, performing dangerous stunts involving falling from horses.
- In 2008, a retrospective of his films was held at the Cinema Ritrovato festival in Bologna, and a temporary exhibition of photographs and film stills documenting Ghione's career was opened at the Cineteca of Bologna.
- He was an Italian silent film actor, director and screenwriter.
- His funeral was held at the Roman Basilica of Santa Maria degli Angeli e dei Martiri, and his remains interred in the Verano cemetery in Rome.
- After his final film role in 1926, Ghione briefly performed on a theatrical tour of Italy.
- In 1914, Ghione created the first film featuring his character Za La Mort, Nelly La Gigolette, which was a great success. Following this success and his move to Tiber film, Ghione created a sequel called Za La Mort (1915), which developed the character and introduced a companion, Za La Vie, played by Kally Sambucini. Ghione created a total of thirteen Za La Mort feature films and three serial films between 1914 and 1924, many of which were very successful commercially.
- Ghione was best known for writing, directing, and starring in the Za La Mort series of adventure films, in which Ghione played a likeable French Apache and 'honest outlaw'.
- Ghione became known for his success in directing the demanding divas of the period, including Lina Cavalieri, Francesca Bertini and Hesperia. However, Ghione was not entirely able to resist their demands - Francesca Bertini allegedly ordered the destruction of all the prints of Don Pietro Caruso because she did not like the outfits she wore in the film.
- Ghione was a fan of luxury automobiles made by Lancia and used them in his films.
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