- Daughter of Clint Eastwood and Frances Fisher.
- On Christmas morning, 2001, Francesca and her mother, Frances Fisher, narrowly escaped a fire that consumed their house. Francesca climbed out her bedroom window and leapt into the arms of her mother and a neighbor, and was treated at a hospital for smoke inhalation. Frances was also treated for burns on her hands. Francesca's father, Clint Eastwood, flew in to visit his daughter in the hospital and personally thanked her rescuers.
- Has played the daughter of both her real-life parents on film: The Stars Fell on Henrietta (1995) with her mother Frances Fisher and True Crime (1999) with her father Clint Eastwood.
- Has a son, Titan Wraith Eastwood (b. September 16, 2018), with her boyfriend Alexander Wraith.
- Chosen to serve as "Miss Golden Globes" for the 70th Golden Globe Awards, alongside that year's "Mr. Golden Globes," Sam Fox (son of Michael J. Fox and Tracy Pollan). Miss or Mr. Golden Globe is a role usually filled by the daughter or son of a celebrity (or celebrities) who has industry ambitions her or himself. Past Miss Golden Globes have included: Linda Evans (1964), Anne Archer (1971), Melanie Griffith (1975), Laura Dern (1982), Joely Fisher (1992), Tori Reid (1999), Dakota Johnson (daughter of 1975 winner Melanie Griffith) (2006), and Lorraine Nicholson (2007). Freddie Prinze Jr. was Mr. GG in 1996.
- Paternal half-sister of Laurie Murray, Kimber Eastwood, Kyle Eastwood, Alison Eastwood, Scott Eastwood, Kathryn Eastwood, Morgan Eastwood, et al.
- (November 25, 2013) Filed for an annulment of marriage from her husband of 8 days Jordan Feldstein.
- Former sister-in-law of Jonah Hill.
- On her father's side, she has English, and some German, Irish, Scottish, and distant Dutch, ancestry. Her mother is of half Ashkenazi Jewish (from Russia and Hungary) and half Norwegian descent.
- Stepdaughter of Dina Eastwood.
- Named Miss Golden Globe 2013 by the Hollywood Foreign Press Association.
- Granddaughter of Ruth Wood.
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