Cathryn de Prume attended NYC's High School of the Performing Arts then began her long standing career starring opposite Melissa Leo as "Goldi Lox" in the indie thriller
Deadtime Stories (1986). That was followed by a role in Five Corners, written by John Patrick Shanley, with
Jodie Foster and
Tim Robbins. Decades of film and television roles include recently appearing opposite
Reese Witherspoon in
Wild (2014) as well as sharing the screen with William H. Macy in
Shameless (2011). She has played con artists, troubled mothers, and a handful of picaresque Russians. She starred for 29 episodes as "Donna Shipko", opposite Anna Gunn and Pamela Adlon, in the Fox sitcom
Down the Shore (1992). She co-wrote
Random Shooting in L.A. (2002). Her one-woman show, Blended Salad, about her eccentric Brooklyn family, was performed in theaters around Los Angeles. She lives in Los Angeles with her husband and daughter.