- Although born in the Dominican Republic, he is half-Dominican (on his mother's side) and half-Puerto Rican (on his father's side). As a result of his father's nationality, he was an American citizen, and lived most of his adult life in the United States.
- Designed gowns worn by First Ladies of the United States beginning with Jacqueline Kennedy, and including Lady Bird Johnson, Pat Nixon, Betty Ford, Rosalynn Carter, Nancy Reagan, Barbara Bush, Hillary Clinton, Laura Bush, and Michelle Obama, an unbroken string of ten presidential wives in a row.
- Adopted son, Moises de la Renta, with his second wife, Annette Reed de la Renta.
- Maintained homes in Manhattan, New York City, New York, USA; Kent, Connecticut, USA; and in the Dominican Republic, the country of his birth.
- Had step-children from both of his marriages.
- Pictured on a 250p Dominican Republic commemorative postage stamp issued 13 October 2015.
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