- Burke lost both parents to cancer. Her mother died in the mid-sixties when Burke was just 2. Her father died in 1985.
- Attended Maria Fidelis Secondary School, Phoenix Road, Euston. Her best friend at school was Kathy Coleman (the two Kathys).
- Burke contracted Clostridium difficile while in hospital for an operation in 2007, resulting in her having to pass directing duties on Dying for It at the Almeida Theatre (which starred Charlie Condou and Sophie Stanton who she worked with on Gimme Gimme Gimme (1999)).
- She took a break from acting in 2002 to concentrate on theatre directing. Since then she has only acted occasionally.
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