- The frequent subject of criticism by Donald Trump, he got revenge on the billionaire by depicting him in Bloom County as a half-cat-half-man who was obsessed with large objects.
- Was close friends with sci-fi comedy author Douglas Adams (1952-2001), as Berke's wife and Douglas both were involved in the same wild life fund (Diana Fossey's Gorilla Fund).
- "Bloom County" eventually appeared in over 1,200 newspapers around the world. He retired the comic on 6 August 1989.
- Daughter Sophie; son Milo.
- Pulitzer Prize, editorial cartoons (1987)
- Has returned to cartooning with the Sunday-only comic strip "Opus," which features the penguin from Breathed's previous two comic strips. (November 2003)
- Still drawing one panel strips of "Opus 'n Bill" for Calendars and promotional purposes. (January 2000)
- Hurt his back once in an ultralight plane accident.
- Was condemned by his readers in the early 1980s for producing so many cartoons making fun of Princess Diana.
- Early in his cartooning career he was accused of imitating G.B. Trudeau's series, Doonesbury.
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