- On the sitcom Black-ish (2014), Laurence Fishburne plays his father and is actually only nine years his elder.
- One of four actors to appear in both the "Scream" franchise and its parody, the "Scary Movie" franchise. The other three are Jenny McCarthy-Wahlberg, Jerry O'Connell and Tori Spelling. Anderson is the only one to appear in the "Scary Movie" franchise before appearing in a "Scream" film.
- Grew up in Compton, California.
- Son of Doris Bowman, a former telephone operator.
- Currently resides in Los Angeles, California. He is married to his college sweetheart and they have two children.
- In Scream 4 (2011), he plays a character named Anthony Perkins, named after the actor who played Norman Bates in Psycho (1960).
- Has co-starred with DMX in three movies: Romeo Must Die (2000), Exit Wounds (2001) and Cradle 2 the Grave (2003).
- Attended Howard University in Washington, D.C.; but was forced to dropped out. Is an honorary member of Omega Psi Phi Fraternity, Inc.
- Nominated for the 2018 Emmy Award in the Lead Actor in a Comedy Series category for his role as Andre 'Dre' Johnson in Black-ish (2014), but lost to Bill Hader from Barry (2018).
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6780 Hollywood Boulevard in Hollywood, California on August 14, 2020 (the day before his 50th birthday).
- Has family residing in the Chicago, Illinois area.
- Attended Hollywood High School Performing Arts Center at the same time as Benito Martinez, his future co-star on The Shield (2002). Anderson was a year behind Martinez.
- Used the line "Don't drop the soap" in two different movies: Barbershop (2002) and King's Ransom (2005).
- Attended and graduated from Hollywood High School Performing Arts Center (1988).
- Favorite NFL football player is Reggie Bush of the New Orleans Saints.
- He was considered to play the Voodoo Maestro in Scooby-Doo (2002), but turned down due to schedule conflicts with Kangaroo Jack (2003). The role went to Miguel A. Núñez Jr..
- His photo double in Cradle 2 the Grave (2003) was actor Dwayne Winstead.
- Has two children with his wife Alvina Anderson: a daughter Kyra (b. 1996) and a son Nathan Anderson (b. 2000).
- Attended the 2006 Dominican International Film Festival in Santo Domingo.
- Nephew of Denise Whitehurst.
- Brother of Derrick Bowman.
- Uncle of Dillion Bowman.
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