Has five children by ex-wife Daphne Wayans (nee Daphne Polk): Jolie (b. June 25, 1992) Nala (b. March 4, 1996) Keenen Jr. (b. September 14, 1998)
Bella (b, March 4, 2001) and Daphne Ivory (b. July 12, 2003).
Keenan attended college at Tuskegee Institute in Alabama but dropped out his senior year to pursue comedy full time. His comic influence is Richard Pryor.
Keenen Ivory Wayans was the first movie director that Hollywood ever allowed to depict a rape scene that was designed specifically for laughs. (Little Man (2006)).