- To this day, he is still close with Dead Poets Society (1989) co-star Ethan Hawke.
- Is very good friends with House (2004) co-star Hugh Laurie.
- Was the first actor to be cast in House (2004).
- Is married to Gabriella Salick, a professional horse racer who is executive director of the West Coast Active Riders. Salick had their first daughter, Eleanor, in January 2009 and their second one, Claudia, in July 2012.
- Took his brother's first name (Sean) as his middle name.
- Won the 2001 Tony Award for Best Featured Actor in a Play for his performance as young A.E. Houseman in Tom Stoppard's "Thie Inventon of Love". His co-star, Richard Easton, won the Tony for Best Actor in a Play for his portrayal of Houseman late in his life. Nominated in the same category two other times: in 1993, for a revival of George Bernard Shaw's "Candida," and in 2003 for a revival of "Long Day's Journey into Night" by Eugene O'Neill.
- He made two films with Kenneth Branagh in 1993: Swing Kids (1993) and Much Ado About Nothing (1993). Branagh also directed the latter.
- In "Long Day's Journey Into Night" on Broadway portraying the role of Edmund. (April 2003)
- Reads the Audiobook for Michael Crichton's Prey.
- In "The Violet Hour" on Broadway portraying the role of John Pace Seavering. (November 2003)
- Attended the Columbia University school of General Studies and Continuing Education.
- Grew up on the same block as actor Casper Van Dien. They raced each other in go-carts.
- He was considered for the role of Norman Bates in Psycho (1998) before Vince Vaughn was cast.
- In Dead Poets Society (1989) his character's father (Kurtwood Smith) wanted him to be a doctor. He then later played a doctor in House (2004), apparently fulfilling his "father's" wishes. The two would be reunited in Half-Wit (2007).
- Co-starring as "Dr. James Wilson" in the popular medical drama House (2004). (December 2004)
- His firstborn daughter has the same first name as Mr & Mrs Bridge Co Stars Paul Newman & Joanne Woodward's born nearly 50 years earlier though spelled differently the elder Eleanor's name is spelled Elinor first name for her maternal grandmother Elinor Trimmier Woodward Carter and middle name after her paternal grandmother Theresa Festko Newman.
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