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- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorGregory Thomas GarciaStarsJason LeeEthan SupleeJaime PresslyA ne'er do well wins $100,000 in the lottery and decides to right all the wrongs from his past with his newfound realization!
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorRob McElhenneyGlenn HowertonStarsCharlie DayGlenn HowertonRob McElhenneyFive friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorRobert CarlockTina FeyStarsEllie KemperJane KrakowskiTituss BurgessA woman is rescued from a doomsday cult and starts life over again in New York City.
- CreatorSol SaksStarsElizabeth MontgomeryDick YorkDick SargentA witch married to an ordinary man cannot resist using her magic powers to solve the problems her family faces.
- CreatorDavid AngellPeter CaseyDavid LeeStarsKelsey GrammerJane LeevesDavid Hyde PierceDr. Frasier Crane moves back to his hometown of Seattle, where he lives with his father and works as a radio psychiatrist.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of sports columnist Ray Barone and his dysfunctional family.4-6/10
- CreatorFred ArmisenCarrie BrownsteinJonathan KriselStarsFred ArmisenCarrie BrownsteinKyle MacLachlanA sketch-comedy series that parodies life in Portland, Oregon.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- StarsCraig T. NelsonJerry Van DykeBill FagerbakkeHayden Fox is the head coach of a university football team, and eats, sleeps and lives football.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorChuck LorreDottie Dartland ZicklinStarsJenna ElfmanThomas GibsonJoel MurrayA free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorCarol BlackNeal MarlensDavid S. RosenthalStarsEllen DeGeneresDavid Anthony HigginsJoely FisherEllen Morgan is a neurotic bookstore owner who deals with life through comedy and extensive rambling.
- CreatorJim PattersonDon ReoStarsAshton KutcherSam ElliottGrady Lee RichmondThe son of a Colorado rancher returns home from a semi-pro football career to run the family business.
- CreatorJennie Snyder UrmanStarsGina RodriguezAndrea NavedoYael GrobglasA young, devout Catholic woman discovers that she was accidentally artificially inseminated.
- CreatorDiane EnglishStarsCandice BergenGrant ShaudRobert PastorelliThe personal and professional misadventures of an opinionated but beloved woman working as a television journalist.
- CreatorGarry MarshallStarsRon HowardHenry WinklerMarion RossThe Cunningham family live through the 1950s with help and guidance from lovable and almost superhuman greaser Fonzie.
- CreatorBrenda HamptonStarsStephen CollinsCatherine HicksJessica BielEric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
- CreatorLarry GelbartStarsAlan AldaWayne RogersLoretta SwitThe staff of an Army hospital in the Korean War find that laughter is the best way to deal with their situation.
- CreatorJames BurrowsGlen CharlesLes CharlesStarsTed DansonRhea PerlmanJohn RatzenbergerThe regulars of the Boston bar "Cheers" share their experiences and lives with each other while drinking or working at the bar where everybody knows your name.