Matthew & April
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- DirectorRob HardyStarsEllen PompeoSandra OhJustin ChambersArizona is grappling with the pain of Phantom Limb when a consultant arrives at the hospital to begin investigations. While Derek embarks on his first major surgery, Meredith faces her biggest fear as she experiences pregnancy mood swings.
- DirectorRob GreenleaStarsEllen PompeoSandra OhJustin ChambersAlex and Jackson are pitted against each other to become the next "face" of Seattle Grace while they work on a sex reassignment surgery for a transgender teen. Then, April brings in an emergency trauma case which requires the help and discretion of many of the doctors. Meanwhile, Callie and Richard visit a recently revitalized hospital to understand what they are all in for.
- DirectorTony PhelanStarsEllen PompeoSandra OhJustin ChambersAs the hospital inches closer to finding a buyer, many of the doctors don't like the new changes being made, causing the crash survivors to consider a crazy idea. Meanwhile, April's relationship with Matthew progresses and she asks Jackson for advice.
- DirectorMark JacksonStarsEllen PompeoSandra OhJustin ChambersWhen a giant gas tanker explodes on a highway, a couple of parents are admitted to the hospital while Owen looks after their son. Matthew is caught in the explosion and is admitted to the hospital while a single mother fights to find out what mysterious illness is plaguing her son.
- DirectorNicole RubioStarsEllen PompeoSandra OhJustin ChambersA couple of Syrian doctors arrive at Grey Sloan Memorial to learn field techniques for war zones. Then, when a series of patients return with post-op infections, one doctor's work falls under suspicion.
- DirectorBobby RothStarsEllen PompeoSandra OhJustin ChambersAt Jackson's request, the CDC arrives at the hospital to begin an investigation surrounding Bailey's patients. April blames Jackson for her breakup with Matthew and Alex tries to be nice to Jason. Owen continues to get closer to Ethan as his dad's health remains uncertain.
- DirectorTony PhelanStarsEllen PompeoSandra OhJustin ChambersWith a major storm rolling in, the hospital is chaotic. When Jason comes into the hospital in critical condition, Alex does everything he can to protect Jo. With Meredith's due date just weeks away, Derek urges her to slow down.
- DirectorRob CornStarsEllen PompeoSandra OhJustin ChambersAs Seattle is plunged into a major storm, Meredith goes into labour. When the hospital loses power, her doctor and all the others are forced to work in the dark. Cristina must perform surgery in almost complete darkness while Arizona, Alex, and Lauren must ward off terrified parents. Then, just outside the hospital, a school bus full of people crashes and flips over, forcing several doctors to rescue its passengers. Cristina finally confronts Owen on his desire to have kids.
- DirectorChandra WilsonStarsEllen PompeoSandra OhJustin ChambersCallie makes a decision about her relationship.
- DirectorKevin McKiddStarsEllen PompeoSandra OhJustin ChambersA betrayal intensifies the issues between Cristina and Meredith; Matthew and April make a decision about their relationship; Bailey faces difficulties with Ben's return.
- DirectorBobby RothStarsEllen PompeoSandra OhJustin ChambersApril's visiting sisters get on her nerves; when Matthew and Jackson witness an accident, they must work together; Callie and Arizona work on their relationship.
- DirectorTony PhelanStarsEllen PompeoSandra OhJustin ChambersMeredith and Cristina bicker about their careers; Bailey talks to Ben about him moving back to Seattle; Shane puts himself in a risky situation; Derek receives a life-changing phone call.
- DirectorRob CornStarsEllen PompeoSandra OhJustin ChambersThe doctors face the consequences of the events that took place at April's wedding. Meredith feels betrayed when Derek goes back on a promise, Alex is furious after returning to the hospital and hearing the news about his father, and Arizona and Callie decide whether or not to move forward together. Meanwhile, Bailey realizes she was wrong about the motive behind Ben's decision to move back to Seattle.
- DirectorRob CornStarsEllen PompeoJustin ChambersChandra WilsonFlashbacks reveal the evolution of April and Jackson's relationship, beginning with their initial meeting, and the years-long process of one of Jackson's patients. Also, April finds out something life changing.
- DirectorKevin Rodney SullivanStarsEllen PompeoJustin ChambersChandra WilsonA young boy's case has a profound impact on the doctors of Grey Sloan Memorial; April faces a surprising patient; Jo deals with her estranged husband.
- DirectorJeannot SzwarcStarsEllen PompeoJustin ChambersChandra WilsonAn agent from U.S. Immigration and Customs Enforcement searches the hospital for an employee; Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently; Arizona treats Matthew Taylor's baby.
- DirectorBill D'EliaStarsEllen PompeoJustin ChambersChandra WilsonOne of Grey Sloan Memorial's own is seriously injured, making the team reflect on what is truly important to them. Meanwhile, Nicole Herman pays a visit to GSM and talks to Arizona about an exciting opportunity.
- DirectorDebbie AllenStarsEllen PompeoJustin ChambersChandra WilsonIt's the day of Jo and Alex's wedding, but things don't go as planned.
- DirectorDebbie AllenStarsEllen PompeoChandra WilsonJames Pickens Jr.Jackson pays a visit to his father that helps set him on the right path.