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- DirectorRobert ZemeckisStarsTom HanksRobin WrightGary SiniseThe history of the United States from the 1950s to the '70s unfolds from the perspective of an Alabama man with an IQ of 75, who yearns to be reunited with his childhood sweetheart.
- DirectorIvan CalbéracStarsBastien BouillonJulien DrionMichel AumontSimple is 26 but he has the intellectual abilities of a three year old. Simple is handicapped. Since the death of his father, he lives with his mother and his younger brother Kléber. But when their mother dies in a car accident, both teenagers are left to their own devices. Kléber is going to take his big brother under his wing but for the two young people life is not a chimera.
- DirectorPetter NæssStarsJosh HartnettRadha MitchellGary ColeA love story between two savants with Asperger's syndrome, a kind of autism, whose conditions sabotage their budding relationship.
- DirectorBarry LevinsonStarsDustin HoffmanTom CruiseValeria GolinoAfter a selfish L.A. yuppie learns his estranged father left a fortune to an autistic-savant brother in Ohio that he didn't know existed, he absconds with his brother and sets out across the country, hoping to gain a larger inheritance.
- DirectorTil SchweigerStarsTil SchweigerJohanna WokalekNadja TillerHedonistic bachelor Nick falls for an escaped mental patient.
- DirectorMick JacksonStarsClaire DanesJulia OrmondDavid StrathairnA biopic of Temple Grandin, an autistic woman who has become one of the top scientists in the humane livestock handling industry.
- DirectorJessie NelsonStarsSean PennMichelle PfeifferDakota FanningAn intellectually disabled man fights for custody of his 7-year-old daughter and in the process teaches his cold-hearted lawyer the value of love and family.
- DirectorDamien O'DonnellStarsJames McAvoySteven RobertsonRomola GaraiWhen the kinetic Rory moves into his room in the Carrigmore Residential Home for the Disabled, his effect on the home is immediate. Most telling is his friendship with Michael, a young man with cerebral palsy and nearly unintelligible speech. Somehow, Rory understands Michael, and encourages him to experience life outside the confines of home.
- 1997–20231h 35mTV-PG7.1 (1.8K)TV EpisodeDirectorNadia TassStarsAlison ElliottHallie EisenbergLucas BlackA television remake of William Gibson's classic play about Annie Sullivan's efforts to draw Helen Keller from her world of darkness, blindness, deafness and silence.
- DirectorArthur PennStarsAnne BancroftPatty DukeVictor JoryThe story of Anne Sullivan's struggle to teach the blind and deaf Helen Keller how to communicate.
- DirectorRanda HainesStarsWilliam HurtMarlee MatlinPiper LaurieA new speech teacher at a school for the deaf falls in love with the janitor, a deaf woman speechless by choice.
- DirectorJames MarshStarsEddie RedmayneFelicity JonesTom PriorStephen Hawking gets unprecedented success in the field of physics despite being diagnosed with motor neuron disease at the age of 21. He defeats awful odds as his first wife Jane aids him loyally.
- DirectorGregg ChampionStarsMary-Louise ParkerAidan QuinnZac EfronA mom is alone with her fraternal twin sons after they're diagnosed with autism. She tries to give them a normal childhood.
- DirectorGeorge MillerStarsNick NolteSusan SarandonPeter UstinovLorenzo Odone, a Virginia 5-year-old, develops a degenerative nerve disease so rare that nobody is working on a cure, so his parents decide to immerse themselves in research and tackle the problem themselves.
- DirectorPeter SegalStarsAdam SandlerDrew BarrymoreRob SchneiderHenry Roth is a man afraid of commitment until he meets the beautiful Lucy. They hit it off and Henry think he's finally found the girl of his dreams until discovering she has short-term memory loss and forgets him the next day.
- DirectorValeriy TodorovskiyStarsChulpan KhamatovaDina KorzunMaksim SukhanovAlyosha has a gambling problem and his girlfriend becomes a stripper to help pay off his debt.
- DirectorMax MayerStarsHugh DancyRose ByrnePeter GallagherAdam, a lonely man with Asperger's Syndrome, develops a relationship with his upstairs neighbor, Beth.
- DirectorRichard EyreStarsJudi DenchJim BroadbentKate WinsletTrue story of the lifelong romance between novelist Iris Murdoch and her husband John Bayley, from their student days through her battle with Alzheimer's disease.
- DirectorDavid DelrieuxStarsJulien BoisselierHélène de FougerollesMarianne BaslerAfter a successful experiment on Algernon, a mouse whose level of intelligence thanks to that procedure dramatically increased, the scientists decided to go further - the next "guinea pig" is Charles, a mentally retarded young man. The experiment is again successful. But what happens after it?
- DirectorJeff BlecknerStarsMatthew ModineKelli WilliamsRichard ChevolleauCharlie Gordon is mentally handicapped and all he wants in life is to be a genius. Charlie takes the chance, but he must adjust emotionally when a laboratory experiment raises his IQ to amazing levels.
- DirectorMichel GondryStarsJim CarreyKate WinsletTom WilkinsonWhen their relationship turns sour, a couple undergoes a medical procedure to have each other erased from their memories forever.
- DirectorChristopher NolanStarsGuy PearceCarrie-Anne MossJoe PantolianoA man with short-term memory loss attempts to track down his wife's murderer.
- DirectorDavid FincherStarsBrad PittCate BlanchettTilda SwintonTells the story of Benjamin Button, a man who starts aging backwards with consequences.
- DirectorMartin BrestStarsAl PacinoChris O'DonnellJames RebhornA prep school student needing money agrees to "babysit" a blind man, but the job is not at all what he anticipated.
- DirectorMarc EvansStarsAlan RickmanSigourney WeaverCarrie-Anne MossA drama focused on the friendship between a high-functioning autistic woman and a man who is traumatized after a fatal car accident.
- DirectorRichard GlatzerWash WestmorelandStarsJulianne MooreAlec BaldwinKristen StewartA linguistics professor and her family find their bonds tested when she is diagnosed with Alzheimer's Disease.
- DirectorPenny MarshallStarsRobert De NiroRobin WilliamsJulie KavnerThe victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them.
- DirectorHenry KosterStarsJames StewartWallace FordWilliam H. LynnDue to his insistence that he has an invisible six foot-tall rabbit for a best friend, a whimsical middle-aged man is thought by his family to be insane - but he may be wiser than anyone knows.
- DirectorFielder CookStarsJames StewartJohn McGiverMarian HaileyElwood P. Dowd's constant companion is Harvey, a six-foot tall invisible rabbit. To his sister, his obsession with Harvey has been a thorn in her plans to marry off her daughter. However, when she decides to put Elwood in a mental institution, a mix-up occurs, and she finds herself committed instead. It's now up to Elwood and "Harvey" to straighten out the mess.
- CreatorScott FrankAllan ScottStarsAnya Taylor-JoyChloe PirrieBill CampOrphaned at the tender age of nine, prodigious introvert Beth Harmon discovers and masters the game of chess in 1960s USA. But child stardom comes at a price.