Deadly Fictional Diseases
Which of the following diseases seen in either television, video games, or film would you say is the worst of the worst?
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35 titles
- DirectorRupert WyattStarsJames FrancoAndy SerkisFreida PintoA substance designed to help the brain repair itself gives advanced intelligence to a chimpanzee who leads an ape uprising.The Simian Flu
- CreatorDavid BenioffD.B. WeissStarsEmilia ClarkePeter DinklageKit HaringtonNine noble families fight for control over the lands of Westeros, while an ancient enemy returns after being dormant for millennia.Greyscale
- DirectorJoel SchumacherStarsArnold SchwarzeneggerGeorge ClooneyChris O'DonnellBatman and Robin try to keep their relationship together even as they must stop Mr. Freeze and Poison Ivy from freezing Gotham City.MacGregor's Syndrome
- DirectorDanny BoyleStarsCillian MurphyNaomie HarrisChristopher EcclestonFour weeks after a mysterious, incurable virus spreads throughout the UK, a handful of survivors try to find sanctuary.Rage (Human Cortico-Deficiency Virus)
- DirectorBobby FarrellyPeter FarrellyStarsLaurence FishburneChris RockDavid Hyde PierceA policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.Red Death
- CreatorDavid X. CohenMatt GroeningStarsBilly WestJohn DiMaggioKatey SagalPhilip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.Bone-itis
- DirectorEli RothStarsJordan LaddRider StrongJames DeBelloFive college graduates rent a cabin in the woods and begin to fall victim to a horrifying flesh-eating virus, which attracts the unwanted attention of the homicidal locals.Flesh Eating Virus
- DirectorPaul W.S. AndersonStarsMilla JovovichMichelle RodriguezRyan McCluskeyA special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.T-Virus
- CreatorSydney NewmanStarsJodie WhittakerPeter CapaldiPearl MackieThe further adventures in time and space of the alien adventurer known as the Doctor and his companions from planet Earth.Bliss Virus
- StarsDoc HarrisChristopher SabatScott McNeilWith the help of the powerful Dragonballs, a team of fighters led by the saiyan warrior Goku defend the planet earth from extraterrestrial enemies.Heart Virus
- CreatorEric KripkeStarsJared PadaleckiJensen AcklesJim BeaverTwo brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.Ghost Sickness
- DirectorRidley ScottStarsHarrison FordRutger HauerSean YoungA blade runner must pursue and terminate four replicants who stole a ship in space and have returned to Earth to find their creator.Methuselah Syndrome
- DirectorNeil MarshallStarsRhona MitraBob HoskinsAlexander SiddigA futuristic action thriller where a team of people work to prevent a disaster threatening the future of the human race.Reaper Virus
- DirectorNeil DruckmannBruce StraleyStarsTroy BakerAshley JohnsonHana HayesIn a hostile, post-pandemic world, Joel and Ellie, brought together by desperate circumstances, must rely on each other to survive a brutal journey across what remains of the United States.Cordyceps Brain Infection
- DirectorSteven SoderberghStarsMatt DamonKate WinsletJude LawHealthcare professionals, government officials and everyday people find themselves in the midst of a pandemic as the CDC works to find a cure.MEV-1
- DirectorRobert WiseStarsJames OlsonArthur HillDavid WayneTop scientists work feverishly in a secret, state-of-the-art laboratory to discover what killed the citizens of a small town and how the deadly contagion can be stopped.The Andromeda Strain
- DirectorJason JonesStarsJen TaylorPete StackerTim DadaboSuper-soldier John-117, Master Chief of the United Nations Space Command, must battle a genocidal alien race known as the Covenant following his violent crash-landing on Halo, an ancient and mysterious ring-world.Flood Parasite
- DirectorWarren SpectorStarsJay Anthony FrankeBrent AndersonRalph BarbagalloIn a dark cyberpunk future where poverty, disease, oppression and terrorism are widespread, J.C. Denton, a new cybernetically-enhanced special agent, finds evidence of a massive conspiracy when his brother, also an agent, goes rogue.Gray Death
- DirectorWolfgang PetersenStarsDustin HoffmanRene RussoMorgan FreemanArmy doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.Motaba
- DirectorGuillermo del ToroStarsMira SorvinoJeremy NorthamAlexander GoodwinThree years ago, entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease. Now, the insects are out to destroy their only predator, mankind.Strickler’s Disease
- DirectorLawrence KasdanStarsMorgan FreemanThomas JaneJason LeeFriends on a camping trip discover that the town they're vacationing in is being plagued in an unusual fashion by parasitic aliens from outer space.The Ripley
- DirectorMo DavoudianStarsJohn DiMaggioCarlos FerroLester SpeightMankind's desperate struggle for survival against a the Locust Horde, a nightmarish race of creatures that surface from the planet's core.Rust Lung
- DirectorAdam SimonDarren Patrick MoloneyStarsDiane LaddRaphael SbargeJennifer RunyonA genetically manipulated and very hungry dinosaur escapes from a bioengineering company and wreaks havoc on the local desert town. A security guard and a girl environmentalist try to stop both it and the company's doomsday bioweapon.Carnosaur Virus
- DirectorRobert LongoStarsKeanu ReevesDolph LundgrenDina MeyerA data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.Nerve Attenuation Syndrome
- DirectorDarren Lynn BousmanStarsPaul SorvinoAnthony HeadAlexa PenaVegaA worldwide epidemic encourages a biotech company to launch an organ-financing program similar in nature to a standard car loan. The repossession clause is a killer, however.Synaptic/Neuro Overstimulation Syndrome
- DirectorKurt WimmerStarsMilla JovovichCameron BrightNick ChinlundA beautiful haemophage infected with a virus that gives her superhuman powers has to protect a boy in a futuristic world, who is thought to be carrying antigens that would destroy all hæmophages.Hemoglophagia
- CreatorFrank DarabontStarsAndrew LincolnNorman ReedusMelissa McBrideSheriff Deputy Rick Grimes wakes up from a coma to learn the world is in ruins and must lead a group of survivors to stay alive.TS-19
- DirectorTodd HowardStarsLiam NeesonMalcolm McDowellRon PerlmanCenturies following nuclear war, a teen leaves the safety of an underground vault in order to find their father, who left in hopes of creating a water purifier.Forced Evolutionary Virus
- CreatorRob GrantDoug NaylorStarsChris BarrieCraig CharlesDanny John-JulesThe adventures of the last human alive and his friends, stranded three million years into deep space on the mining ship Red Dwarf.Space Mumps
- CreatorSteven KaneHank SteinbergStarsEric DaneAdam BaldwinCharles ParnellThe crew of a naval destroyer is forced to confront the reality of a new existence when a pandemic kills off most of the earth's population.Red Flu
- CreatorJ. Michael StraczynskiStarsMira FurlanRichard BiggsStephen FurstIn the mid 23rd century, the Earth Alliance space station Babylon 5, located in neutral territory, is a major focal point for political intrigue, racial tensions and various wars over the course of five years.Drafa Plague
- CreatorJoss WhedonStarsNathan FillionGina TorresAlan TudykFive hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.Bowden's Malady
- CreatorGene RoddenberryStarsPatrick StewartBrent SpinerJonathan FrakesSet almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.Barclay's Protomorphosis Syndrome
- DirectorDan TudgeStarsSteve ValentinePeter RenadayKate MulgrewAfter four hundred years since the last Blight, a new Archdemon seeks to destroy the land of Ferelden. It is up to the player - as one of the remaining Grey Wardens - to unite the divided armies of Ferelden and save humanity.Blight Disease
- CreatorChris CarterStarsDavid DuchovnyGillian AndersonMitch PileggiTwo F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.Purity