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- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorSherry BilsingEllen KreamerStarsJaime PresslyKatie FinneranKevin RahmA story of two life-long friends who realize their children have turned out to be the same type of unlikable bullies that made high school insufferable.
- CreatorFran DrescherPeter Marc JacobsonStarsFran DrescherJohn Michael HigginsTichina ArnoldIn their 18 years of marriage, a middle-aged couple tries to move on with their lives after the husband confesses he's gay.
- CreatorJonathan E. SteinbergStarsMark ValleyChi McBrideJackie Earle HaleyA unique bodyguard protects his clients by secretly infiltrating their lives in order to draw out and eliminate threats.
- CreatorLiz TigelaarStarsShiri ApplebyKristoffer PolahaBritt RobertsonAfter 15 years in foster homes, Lux decides to get emancipated, which leads to her meeting her birth parents.
- CreatorMatt OlmsteadNick SantoraStarsDomenick LombardozziBrooke NevinMalcolm GoodwinA squad of U.S. marshals team up with cons (former fugitives) to work together on tracking down prison escapees in exchange for getting time off their sentences.
- CreatorDan BerendsenStarsSkyler SamuelsGracie GillamKi Hong LeeA girl with special cat-like powers is being hunted by an assassin.
- CreatorChristopher MurpheyStarsDana DelanyJeri RyanGeoffrey ArendMedical examiner Megan Hunt's unique approach to solving crimes puts her at odds with her superiors.
- CreatorVeena SudStarsMireille EnosJoel KinnamanBilly CampbellA police investigation, the saga of a grieving family, and a Seattle mayoral campaign all interlock after the body of 17-year-old Rosie Larsen is found in the trunk of a submerged car.
- CreatorDarlene HuntStarsLaura LinneyOliver PlattGabriel BassoA suburban mother faces her cancer diagnosis while trying to find humor and happiness as well.
- CreatorSamuel BaumStarsTim RothKelli WilliamsBrendan HinesAbout Cal Lightman, the world's leading deception expert who studies facial expressions and involuntary body language to expose the truth behind the lies.
- CreatorGlenn KesslerTodd A. KesslerDaniel ZelmanStarsGlenn CloseRose ByrneTate DonovanA law school graduate becomes the protégée of a successful high-stakes litigator.
- CreatorJoss WhedonStarsEliza DushkuHarry LennixFran KranzA top secret organization erases the identities of attractive young people, turning them into blank "dolls" ready for imprints of temporary identities they need to fulfill assignments for clients.
- CreatorFernando GaitánSilvio HortaStarsAmerica FerreraEric MabiusTony PlanaSmart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- CreatorJennifer JohnsonStarsKelli GiddishCole HauserJesse MetcalfeA team tracks down fugitive criminals.
- CreatorChuck LorreStarsBrett ButlerCasey SanderKaitlin CullumGrace is a recovering alcoholic, now divorced from an abusive husband, struggling to bring up three children on her own.
- CreatorBryan FullerStarsLee PaceAnna FrielChi McBrideA pastry chef with the power to bring dead people back to life solves murder mysteries with his resurrected childhood sweetheart, a cynical private investigator, and a lovesick waitress.
- CreatorTara ButtersMichele FazekasStarsBret HarrisonTyler LabineRick GonzalezOn his 21st birthday, Sam discovers his parents sold his soul to the devil before birth and he must now be a bounty hunter for the devil until he dies.
- CreatorTerri MinskyStarsSara RueZachary LeviAndrea ParkerHuge egos. Backbiting assistants. Screaming deadlines. Claudia "Claude" Casey has moved up in the secretarial world of television news, from permanent floater to the anchor's desk. Can she melt the hearts of the competitive up-and-comers?
- CreatorJ.J. AbramsAlex KurtzmanRoberto OrciStarsAnna TorvJoshua JacksonJohn NobleAn F.B.I. agent is forced to work with an institutionalized scientist and his son in order to rationalize a brewing storm of unexplained phenomena.
- CreatorElizabeth KrugerCraig ShapiroStarsCallie ThorneScott CohenMehcad BrooksA psychotherapist's private life comes apart at the seams when she discovers that her husband is cheating on her. Dr. Dani Santino throws herself fully into her work and soon becomes the most sought-after therapist for celebrity clients.
- CreatorJohn J. McLaughlinMarti NoxonStarsElisabeth HarnoisGrant ShowSam PageA series of supernatural events begins in a small coastal New Jersey town after the arrival of a mysterious teenage girl, who apparently has the ability to influence the people and events around her.
- CreatorSteve FranksStarsJames Roday RodriguezDulé HillTimothy OmundsonWhen a novice sleuth convinces the police he has psychic powers, he and his reluctant best friend are hired on as consultants to help solve complicated cases.
- CreatorCynthia SaundersStarsAlly WalkerJulian McMahonA MartinezDr. Sam Waters is a detective with the Violent Crimes Task Force, a federal agency which often works with the FBI, ATF, and other crime-solving agencies.
- CreatorAlan BallStarsPeter KrauseMichael C. HallFrances ConroyA chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.