Audrey has a sister named Zoe in the series, traditionally Lil' Audrey has a brother with whom she nicknames Patches.
Little Audrey's iconic dress that she has worn in the comics and animated shorts have been replaced with a long sleeved shirt with a lightening bolt, pants and sneakers.
Harvey Street Kids will finally mark the animated debut of Little Lotta and Little Dot who have only appeared in the Harvey Comics.
Joey McIntyre, Nick Lachey, Joey Fatone and Shawn Stockman will provide the voices to the members of the show's band Crush4U.
Lotta is the only Harvey comics character to have been adapted into live-action before animation, she as well as Audrey appeared in the straight-to-video release Baby Huey's Great Easter Adventure in 1999.