This marks the 276th episode of the series, making it the longest-running multi-camera sitcom ever. Cheers (1982) previously held the title with 275 episodes.
When Dr. Greg Pemberton says, "That's the great thing about science, we all get to have our own opinions." it's a throwback to The Justice League Recombination (2010), when Zack tells Leonard a similar line, "That's what I love about science, there's no one right answer", implying that Pemberton has as little intelligence about science as Zack.
A scene where Howard goes to the Cheesecake Factory with Raj to find the waitress who had a crush on him was shot, but was omitted from the episode. Mimi Gianopulos still gets credited for the deleted scene, though.