Lin-Manuel Miranda (Episode 6) is actually a longtime fan and friend of the McElroy three, consistently making sly reference to their work and appearing on episode 193 of the podcast which this show is based off of.
Most of the show was improvised with each twenty minute episode being made from hours of footage
A phenomena associated with the brothers leaves one saying "I'm horny for this one".
Based on the podcast of the same name, which has been running since 2010.