In light of Cobain's suicide in 1994, Allmusic's Mark Deming suggests that hearing "Cobain sing 'and I swear that I don't have a gun' gives 'Come as You Are' an edge it was never meant to have when "Nevermind" was first released in 1991." Deming reasons that the "I don't have a gun" lyric is Cobain's "attempt to reassure listeners that ... his target is the world at large rather than the individuals in it, and that there was still room in this damaged world for everyone".
In 2005, a sign was put up in Aberdeen, Washington, Cobain's hometown, that reads "Welcome to Aberdeen: Come As You Are" as a tribute to Cobain. The sign was paid for and created by the Kurt Cobain Memorial Committee, a non-profit organization created in May 2004 to honor Cobain.
A remix of the song was used for trailers of "Marvel's" 2017 Netflix series "The Defenders."
It was the band's second American Top 40 hit, and second UK top 10 hit, reaching number 32 on the Billboard Hot 100, and number nine on the UK Singles Chart.
Following the album's release, the band and its management company debated whether to release "Come as You Are" or "In Bloom" as the next single from the album due to Cobain's concerns over similarity of the former with the Killing Joke song "Eighties" (1984).