Ex-black ops CIA agents Frank Moses (
Bruce Willis) and Marvin Boggs (
John Malkovich) , now considered RED (Retired, Extremely Dangerous), reunite with retired MI6 sharpshooter Victoria Winsler (
Helen Mirren) to track down Nightshade, a portable nuclear weapon smuggled in pieces and hidden in the Russian Kremlin by physicist Edward Bailey (
Anthony Hopkins), whom MI6 has kept incarcerated in a London asylum for the past 32 years. Aided by Frank's girlfriend Sarah (
Mary-Louise Parker) and Russian secret agent Katja Petrocovich (
Catherine Zeta-Jones), the five attempt to retrieve the Nightshade device while dodging South Korean contract killer Han Cho Bai (
Lee Byung-hun) and Pentagon agent Jack Horton (
Neal McDonough).