When shooting the Lambent Brumak with the Hammer of Dawn, the laser is still hitting the Brumak even tho Marcus is no longer holding the weapon itself.
The weapons flip when changing position; bolts that were right-hand bolts become left-hand bolts, and shells eject from the other sides of the weapons.
In the research facility, the door that Sergeant Fenix and Dom both have to open at the same time is a gate, but turns into a solid door.
Spelling and grammar mistakes are present in the in-game text.
The remains of the turret on the gunboat that was ripped off after the gunboat fell down the waterfall are completely smooth as if no turret was ever mounted.
A pair of doors at the Archives opens on its own when all the enemies are killed.
Considering how much effort was needed to get the grindlifts into the caverns at the beginning of the game, it is not explained how Sergeant Fenix knew that Baird and Cole would be able to take one into the Nexus.
No one thinks to ask why the Locus Queen speaks English.
Baird somehow knew of the existence of two Reavers behind the Locust Queen's palace even though he couldn't have seen them.
It is not explained why Dom and Sergeant Fenix had to climb down into the Jacinto sinkhole even though a helicopter was bringing the lightmass bomb down anyway.
Upon picking up the flamethrower for the first time, Marcus and Don lament that the late Carmine 'always talked about fire'. Carmine never talked about fire.