- James Lipton - Host: What is your favorite curseword?
- Robert Downey Jr.: Seven syllables: son of a cock-loving whore!
- James Lipton - Host: You've said "'Home for the Holidays' was, for me, one of the most relaxed performances in the history of cinema."
- Robert Downey Jr.: Yeah.
- James Lipton - Host: What was relaxing you?
- Robert Downey Jr.: [immediately] Black tar heroin.
- James Lipton - Host: [taken aback] What?
- Robert Downey Jr.: [laughs; to audience] Do you see how sweet and innocent he is about this stuff?
- James Lipton - Host: I'm from Michigan. I'm square.