The original plan for this episode was to bring back Reese Witherspoon as Jill Green, however Witherspoon was unavailable so the writers re-wrote the role as Amy Green and cast Christina Applegate in the role. Applegate went on to win an Emmy for her performance in the episode.
Christina Applegate won an Emmy Award for Outstanding Guest Actress in a Comedy Series for this episode.
This is the first Thanksgiving episode where there is no mention of Chandler's aversion to all Thanksgiving food.
One of the episodes that was submitted from the show at The 55th Annual Primetime Emmy Awards (2003) for Outstanding Comedy Series.
Christina Applegate and Matt Leblanc also appeared on the sitcom "Top of the Heap" together, along with "Married With Children". So when she appeared on "Friends" as Rachel's sister Amy in the Thanksgiving themed "The One With Rachel's Other Sister" that was actually the third time they had appeared together.