"George and Martha" shares a theme song with another HBO series Real Sex (1990), a decidedly less family-oriented show.
Nathan Lane and Andrea Martin are the only American voice actors. Everyone else in the cast was based in Toronto, Ontario, Canada.
George and Martha was turned into an original musical, George and Martha: Tons of Fun, by Imagination Stage in Bethesda, Maryland in 2011. It featured music, books, and lyrics by Joan Cushing and was directed by Kathryn Chase Bryer.