Gene Wilder, Jon Lovitz, and Steve Martin were considered for the voice of Eek, eventually the role went to co-creator Bill Kopp who used a voice he and his siblings had come up with for one of their cats.
The show hasn't got a North American DVD release ever since after Saban Entertainment was acquired by The Walt Disney Company in 2001. Since acquiring the rights to the show, no word from Disney has been spoken about releasing the series to DVD in North America.
As observed by animation historian Don Markstein (1947-2012), the series was indented as a parody of several "family-friendly" animated series of the 1970s and 1980s. At the time, powerful "parent action groups" demanded series which emphasized the values of altruism, kindness, sharing, etc. Eek embodies altruism and selflessness in his constant desire to help others, and to prioritize others' needs before his own. But instead of being rewarded for volunteering to help, Eek constantly gets involved in painful or life-risking situations.
Eek was originally going to be a pink-colored cat but was changed to purple.
The show's original title was "The Six and a Half Lives of Eek The Cat".