The hospital where Matthew Modine's character is interning in was in fact a real hospital in Los Angeles that shut down but was then converted and used as a movie and TV show set. Director Thom Eberhardt while filming had a feeling that he had been there before and someone reminded him that he in fact had been born there. Eberhardt happily responded with saying "Whoa cool"
In order to get the limp that Christine Lahti's character Dr. Rachel Woodruff has in the film, she took off her wedding ring and put it in her shoe so she wouldn't forget that she had it.
The scene where Matthew Modine and Daphine Zuniga are talking on the porch in front of Modine's parents house was an all night shoot and it was an urgent final shot by Director Thom Eberhardt because sun was just starting to come up and was really happy that it took only one take to get it.
The scene where Daphine Zuniga has her rant was almost completely ad-libbed.
Matthew Modine was not the first choice to play Joe Slovak.