- On February 13, 2018, she married her boyfriend of three months, chef Chris Fischer, in a private ceremony in Malibu, California before 80 guests which included her close friends Jennifer Aniston and Jennifer Lawrence.
- Second cousin, once removed, of United States Senator Chuck Schumer. Amy's paternal great-great-grandparents, Abraham Schumer and Joder Ida/Edith Wizman, were also Chuck's paternal great-grandparents.
- After college, she moved to New York City to become an actress. She tended bar and waited tables while she auditioned for various roles.
- She is the daughter of Sandy Schumer (née Jones) and Gordon Schumer. Her father was born to a Jewish family (from Ukraine and Poland). Her mother's ancestry includes English and German, as well as some Scottish and Welsh; Amy's mother converted to Judaism. Amy went to Hebrew School and had a Bat Mitzvah ceremony.
- Younger sister Kim Caramele is her road manager, comedy co-writer and associate producer. Also has a half-brother, Jason Stein, who is a jazz musician and plays bass clarinet.
- Claims to have kept detailed journals of every day of her life between the ages of 13 and 23, a source that provided her with much of the material used in her book "The Girl with the Lower Back Tattoo" (2016).
- Received her Bachelor of Arts degree in Theater from Towson University (2003). Also graduated from the William Esper Studio, and from William Esper's two-year Sanford Meisner Intensive program.
- Favorite comedians are Judy Gold, Jessica Kirson, Wendy Liebman, Sarah Silverman, Margaret Cho and Ellen DeGeneres. She is also a huge fan of the New York Mets.
- Long Island, New York native residing in Brooklyn, New York.
- Husband Chris Fischer, from Martha's Vineyard, is a farmer and chef who worked in restaurants such as Mario Batali's Babbo (NYC), St. John Bread and Wine (London), The River Café (London), Beach Plum Inn & Restaurant (Massachusetts) (one of Barack Obama's favorites). Fischer's cookery book "The Beetlebung Farm Cookbook: A Year of Cooking on Martha's Vineyard" was published in 2015.
- Mother, with husband Chris Fischer, of son Gene David Fischer (born May 5, 2019). His middle name was a tribute to the comedian Dave Attell, who was friends with Schumer.
- Attended and graduated from South Side High School in Rockville Centre, New York (1999). She was voted both "Class Clown" and "Teacher's Worst Nightmare" upon graduation.
- Was pregnant with her son Gene during the filming of the second season of Only Murders in the Building (2021). She returned to work two weeks after giving birth Gene via Caesarean section to give a stand-up performance on stage.
- In September 2020, Schumer, along with Elizabeth Banks, Zoe Saldana, Rory O'Malley and Amber Heard, uses her social media presence to participate in the VoteRiders #IDCheck Challenge to help spread the word about voter ID requirements for the 2020 United States presidential election.
- Hosts her own podcast "3 Girls, 1 Keith" with friends Bridget Everett, Rachel Feinstein and Keith Robinson, that premiered on Spotify in June 2018.
- When Amy photo-bombed Kimye at the Time 100 Gala 2015 in New York by falling face down on the red carpet in their path, she was wearing a David Meister outfit. (April 2015)
- In April 2018, she spent five days in the hospital with a "horrible" kidney infection.
- Stand-up comedian.
- In September 2021, she had her uterus removed to alleviate symptoms related to her endometriosis.
- Is a third cousin, once removed, of actor and model Justin Chambers. Amy's maternal great-great-grandfather Edward E. Dement and Justin's maternal great-grandmother Sarah Esther Dement were siblings.
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