Her father, Victor Yustman, was born in Bogotá, Colombia, to a Polish Jewish father and an Italian mother. He was raised in Nicaragua. Her mother, Lydia (Nodarse) Yustman, is Cuban. Odette is fluent in Spanish.
Gave birth to her first child at age 30, daughter Charlie Mae Annable, on September 7, 2015. Child's father is her husband, Dave Annable. The couple met when she guest-starred with him during a five-episode character arc on Brothers & Sisters (2006). They wed on October 10, 2010.
Attended Riverside (CA) Community College and Riverside (CA) Christian School.
Ranked #88 in "FHM" Magazine's Sexiest Women in the World List of 2008.