- One of the jobs he had before becoming a director was a blacksmith.
- For part of his career, he worked at Universal Pictures under producer Paul Kohner, where he would direct films for the Spanish-language market, even though he neither spoke nor understood Spanish. He directed the technically well-regarded---yet quite sub-par due to its comical titular protagonist---Spanish-language version of Bela Lugosi's masterpiece, Dracula (1931), called Drácula (1931)).
- After he retired from directing, he took up a second career as a character actor and appeared in quite a few films.
- During the days of factory-produced silent pictures, Melford's booming voice often disrupted adjacent productions (annoying casts and crews). He quickly acquired the nickname "Whispering George.".
- Died of heart disease in Hollywood, CA. He was buried at Valhalla Memorial Park in North Hollywood, CA.
- Graduated from McGill University in Montreal, Canada.
- Although his first wife Louise Marsland named Jacqueline Logan in her divorce decree, granted 1/10/1924 (she filed the complaint 9/28/1923), when the divorce became final on 1/26/1925 Melford announced that he intended to wed Diana Miller. The couple officially announced their engagement in September 1925 and were wed 11/26/1925.
- Stepfather of Judson Melford. He appeared with him on several films between 1911 and 1913.
- Born George Knauff, he adopted the last name "Melford" because he thought it was more artistic.
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