- She is not related to Michael Keaton, as her birth name is Diane Hall. She changed her last name to her mother's maiden name as a result of a Diane Hall already being in the Actors Guild. According to her, Michael Keaton had a similar problem with his natural name when entering the Guild after his birth name is Michael Douglas (not related to Kirk Douglas's son, Michael Douglas), though he picked "Keaton" because he liked Diane's name.
- Claims she hasn't dated anyone in 35 years. (July 2019)
- Has two adopted children: a daughter Dexter Keaton (b. 1995) and a son Duke Keaton (b. 2000).
- Had a 20-year intermittent relationship with Al Pacino.
- Woody Allen wrote her starring vehicle, Annie Hall (1977), with her in mind. Her real name is Diane Hall and her nickname is Annie.
- Was part of the original cast of the Broadway musical "Hair" (1968).
- Favorite scene: reuniting with Beatty at the train station in Reds (1981).
- Revived the fashion style created by Marlene Dietrich and Katharine Hepburn, when women all over the world started to wear suits and ties; first recognized by the public in Annie Hall (1977).
- Revealed her secret skin cancer surgery. (November 21, 2011)
- Woody Allen said of her, "In real life, Keaton believes in God. But she also believes that the radio works because there are tiny people inside it."
- Among the things she treasures is a tile from James Stewart 's house, which she took when it was being demolished.
- Warren Beatty originally offered Keaton Julie Christie's part in Heaven Can Wait (1978), but decided against it to do the more challenging role in Looking for Mr. Goodbar (1977). She did however take the role of Louise Bryant in Reds (1981), a role which Beatty originally offered to Christie.
- When Keaton was starting out as an actress, she very briefly used her sister's name, Dorrie Hall.
- As of 2014, has appeared in five films that were nominated for the Best Picture Oscar: The Godfather (1972), The Godfather Part II (1974), Annie Hall (1977), Reds (1981) and The Godfather Part III (1990). Of those, The Godfather (1972), The Godfather Part II (1974) and Annie Hall (1977) are winners in the category.
- She's the oldest of four children. Diane has a brother named Randy Hall (b. 1948) and two sisters named Robin Hall (b. 1951) and Dorrie Hall (b. 1953).
- Her performance as Annie Hall in Annie Hall (1977) is ranked #60 on Premiere Magazine's 100 Greatest Performances of All Time. (2006)
- Two of her four Oscar-nominated roles were directed by her then boyfriends: Annie Hall (1977) (which won her an Oscar) was directed by Woody Allen and Reds (1981) was directed by Warren Beatty.
- She and Woody Allen made 8 movies together: Play It Again, Sam (1972), Sleeper (1973), Love and Death (1975), Annie Hall (1977), Interiors (1978), Manhattan (1979), Radio Days (1987) and Manhattan Murder Mystery (1993).
- Has adult-onset asthma.
- She wrote a memoir about her relationship with her alcoholic brother Randy titled "Brother & Sister", published in 2020. In it, she published a letter that her brother wrote to her after seeing her in one of her films: "There are times in Reds (1981) when I wanted to stop the projector, so the moment wouldn't move so fast. Where did you learn to use your face so well? I think you ran across every emotion in the book, then threw the book away and made up some of your own". When a journalist read the letter back to her, Diane could barely hold back her tears when she responded, "That was sweet of him. I don't know what to say....I'm sorry.".
- Revealed her younger brother, 71-year-old Randy Hall, has dementia. (May 1, 2019)
- Was nominated for Broadway's 1969 Tony Award as Best Supporting or Featured Actress (Drama) for "Play It Again, Sam," a performance she recreated in the film version with the same title, Play It Again, Sam (1972).
- Born in the Highland Park neighborhood of Los Angeles.
- She has appeared in four films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Godfather (1972), The Godfather Part II (1974), Annie Hall (1977) and Manhattan (1979).
- One of People Magazine's 50 Most Beautiful People (2004).
- Shares the same birthday with her The Godfather (1972) castmate, Robert Duvall, and The Other Sister (1999) castmate, Joe Flanigan.
- In both her 1977 films, Annie Hall (1977) and Looking for Mr. Goodbar (1977), The Godfather (1972) is referenced. In "Annie Hall," Woody Allen mentions the film as two men bother him for an autograph outside a movie theater. In "Goodbar", Theresa (Keaton) is seen reading Mario Puzo's "The Godfather" at a bar counter when Richard Gere approaches her.
- Was cited as one of the most promising movie personalities of 1973 in John Willis' 1974 Film Annual "Screen World" book.
- The American Film Institute bestowed upon her the 2017 AFI Life Achievement Award, which "honors an individual whose career in motion pictures or television has greatly contributed to the enrichment of American culture.".
- She and Tuesday Weld, who played her sister in Looking for Mr. Goodbar (1977), had intersecting, on-and-off-again romances with Al Pacino. Al was intermittently involved with Weld spanning roughly 1972 to 1982 and Diane from 1971 to 1991.
- Has a street named after her in front of Santa Ana High school in Santa Ana, California, of which she is an alumna.
- Studied acting under the legendary acting teacher, Sanford Meisner, at NYC's prestigious Neighborhood Playhouse.
- She is of Irish, Northern Irish, English, Scottish, German, and distant Austrian, Dutch, and French, ancestry.
- Born to Jack Hall (1921-1990), a civil engineer, and Dorothy Keaton (1921-2008), no profession.
- Chosen by Empire magazine as one of the "100 Sexiest Stars in Film History" (#46). (1995)
- She wanted to direct a remake of the film The Blue Angel (1930) (aka "The Blue Angel") with Madonna in the lead but the project was canceled.
- Shared the cover of Vanity Fair magazine's 2016 Hollywood issue with, Jane Fonda, Viola Davis, Cate Blanchett, Jennifer Lawrence, Rachel Weisz, Lupita Nyong'o, Brie Larson, Alicia Vikander, Gugu Mbatha-Raw, Helen Mirren, Charlotte Rampling and Saoirse Ronan. Photographed by Annie Leibovitz.
- Although she played Teresa Wright's granddaughter in The Good Mother (1988), she is only 27 years her junior in real life.
- Appeared in a commercial for L'Oreal Paris' "Age Perfect" skin care makeup. (2010)
- Is one of 12 actresses who won the Best Actress Oscar for a movie that also won the Best Picture Oscar (she won for Annie Hall (1977)). The others are Claudette Colbert for It Happened One Night (1934), Luise Rainer for The Great Ziegfeld (1936), Vivien Leigh for Gone with the Wind (1939), Greer Garson for Mrs. Miniver (1942), Louise Fletcher for One Flew Over the Cuckoo's Nest (1975), Shirley MacLaine for Terms of Endearment (1983), Jessica Tandy for Driving Miss Daisy (1989), Jodie Foster for The Silence of the Lambs (1991), Gwyneth Paltrow for Shakespeare in Love (1998), Hilary Swank for Million Dollar Baby (2004) and Frances McDormand for Nomadland (2020).
- Is one of 3 actresses to have won the Best Actress Academy Award for their portrayal of a character named "Annie". The others are Anne Bancroft (for The Miracle Worker (1962)) and Kathy Bates (for Misery (1990)).
- In Summer stock, after her training, she appeared in 'The Importance of Being Ernest' and 'Oh! What a Lovely War'among other productions and much later the stage production of 'Play It Again Sam'.
- Dated artist Edward Ruscha in the mid-1970s.
- Was the 81st actress to receive an Academy Award; she won the Best Actress Oscar for Annie Hall (1977) at The 50th Annual Academy Awards (1978) on April 3, 1978.
- Received The Hollywood Reporter's 2012 Sherry Lansing Leadership Award on December 5, 2012.
- Is one of 15 Oscar-winning actresses to have been born in the state of California. The others are Fay Bainter, Gloria Grahame, Jo Van Fleet, Liza Minnelli, Tatum O'Neal, Sally Field, Anjelica Huston, Cher, Jodie Foster, Helen Hunt, Gwyneth Paltrow, Angelina Jolie, Marcia Gay Harden and Brie Larson.
- Is one of 14 actresses to have won both the Best Actress Academy Award and the Best Actress in a Comedy/Musical Golden Globe for the same performance; hers being for Annie Hall (1977). The others, in chronological order, are: Judy Holliday for Born Yesterday (1950), Julie Andrews for Mary Poppins (1964), Barbra Streisand for Funny Girl (1968), Liza Minnelli for Cabaret (1972), Glenda Jackson for A Touch of Class (1973), Sissy Spacek for Coal Miner's Daughter (1980), Cher for Moonstruck (1987), 'Jessica Tandy for Driving Miss Daisy (1989), Helen Hunt for As Good as It Gets (1997), Gwyneth Paltrow for Shakespeare in Love (1998), Reese Witherspoon for Walk the Line (2005), Marion Cotillard for La Vie En Rose (2007), and Jennifer Lawrence for Silver Linings Playbook (2012).
- Is one of 25 actresses to have won an Academy Award for their performance in a comedy; hers being for Annie Hall (1977). The others, in chronological order, are: Claudette Colbert (It Happened One Night (1934)), Loretta Young (The Farmer's Daughter (1947)), Josephine Hull (Harvey (1950)), Judy Holliday (Born Yesterday (1950)), Audrey Hepburn (Roman Holiday (1953)), Goldie Hawn (Cactus Flower (1969)), Glenda Jackson (A Touch of Class (1973)), Lee Grant (Shampoo (1975)), Maggie Smith (California Suite (1978)), Mary Steenburgen (Melvin and Howard (1980)), Jessica Lange (Tootsie (1982)), Olympia Dukakis (Moonstruck (1987)), Cher (Moonstruck (1987)), Jessica Tandy (Driving Miss Daisy (1989)), Mercedes Ruehl (The Fisher King (1991)), Marisa Tomei (My Cousin Vinny (1992)), Dianne Wiest (Bullets Over Broadway (1994)) Mira Sorvino (Mighty Aphrodite (1995)), Frances McDormand (Fargo (1996)), Helen Hunt (As Good as It Gets (1997)), Judi Dench (Shakespeare in Love (1998)), Gwyneth Paltrow (Shakespeare in Love (1998)), Penélope Cruz (Vicky Cristina Barcelona (2008)), and Jennifer Lawrence (Silver Linings Playbook (2012)).
- Shares the same birthday with eponymous television interviewer Charlie Rose (1991), with four years age difference between them, with Charlie Rose, being born January 5, 1942, and Diane's birthday being January 5, 1946, with Diane being an interview subject at Charlie's famous round oak table at least four times between 2003 and 2011.
- Born at 2:49 a.m. PST.
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