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- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- StarsJemima RooperMorven ChristieAlex KingstonAmanda, an ardent Jane Austen fan, lives in present day London with her boyfriend Michael, until she finds she's swapped places with Austen's fictional creation Elizabeth Bennet.
- StarsColin FirthJennifer EhleSusannah HarkerWhile the arrival of wealthy gentlemen sends her marriage-minded mother into a frenzy, willful and opinionated Elizabeth Bennet matches wits with haughty Mr. Darcy.
- CreatorPeter S. FischerRichard LevinsonWilliam LinkStarsAngela LansburyWilliam WindomRon MasakProfessional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.
- CreatorDeborah Joy LeVineJoe ShusterJerry SiegelStarsDean CainTeri HatcherLane SmithIn addition to fighting evil, Superman has a burning romance with Lois Lane in both of his identities.
- StarsStephen FryHugh LaurieRichard DixonBertram Wooster, a well-intentioned, wealthy layabout, has a habit of getting himself into trouble and it's up to his brilliant valet, Jeeves, to get him out.
- StarsPeter KrauseJulianna MarguliesPeter JacobsonA detective investigates a mysterious motel room which acts as a portal to anywhere in the world.
- StarsFrancesca AnnisJustine WaddellBill PatersonThe daughter of a country doctor copes with an unwanted stepmother, an impetuous stepsister, burdensome secrets, the town gossips, and the tug on her own heartstrings for a man who thinks of her only as a friend.
- CreatorEric BressJ. Mackye GruberStarsMatt DallasMarguerite MacIntyreBruce ThomasA family takes in a formerly institutionalized teen savant who is missing standard human behaviors such as anger, joy, and love.
- CreatorJanice DickinsonStuart KrasnowStarsJanice DickinsonPeter HammJ.P. CalderonWhile getting her modeling agency off the ground, Janice Dickinson sifts through 500 contestants to find her 5 finalists.
- CreatorSamuel BaumStarsTim RothKelli WilliamsBrendan HinesAbout Cal Lightman, the world's leading deception expert who studies facial expressions and involuntary body language to expose the truth behind the lies.
- CreatorMichael PillerChristopher TeagueStarsGenevieve PadaleckiNicole TubiolaNana VisitorAfter serving time in a juvenile detention center for stealing a car, Kristine secures a job as a stable hand at Raintree Farms. As she works her way up to jockey, she finds romance and competition from Raintree's rivals, the Davis Farm.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of sports columnist Ray Barone and his dysfunctional family.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- StarsChris O'DowdRichard AyoadeKatherine ParkinsonThe comedic misadventures of Roy, Moss and their grifting supervisor Jen, a rag-tag team of IT support workers at a large corporation headed by a hotheaded yuppie.
- CreatorAlfred GoughMiles MillarStarsTom WellingMichael RosenbaumAllison MackA young Clark Kent struggles to find his place in the world as he learns to harness his alien powers for good and deals with the typical troubles of teenage life in Smallville, Kansas.
- CreatorRyan MurphyStarsDylan WalshJulian McMahonJoely RichardsonTwo plastic surgeons--one a dedicated family man and one an unscrupulous playboy--strive to maintain their business whilst having to work their way through numerous hardships ranging from personal to clients with criminal connections.
- CreatorRené EchevarriaScott PetersStarsJacqueline McKenzieJoel GretschPatrick John FluegerAs the reappearance of 4,400 missing persons on a single day confounds the global community, federal agents on the case slowly discover the ways in which the victims have been changed.
- CreatorHoward OvermanStarsNathan Stewart-JarrettJoe GilgunIwan RheonA group of young offenders doing community service gets struck by lightning during a storm and start to develop superpowers.
- CreatorJ.J. AbramsJeffrey LieberDamon LindelofStarsJorge GarciaJosh HollowayYunjin KimThe survivors of a plane crash are forced to work together in order to survive on a seemingly deserted tropical island.
- CreatorTerri MinskyStarsSara RueZachary LeviAndrea ParkerHuge egos. Backbiting assistants. Screaming deadlines. Claudia "Claude" Casey has moved up in the secretarial world of television news, from permanent floater to the anchor's desk. Can she melt the hearts of the competitive up-and-comers?
- StarsStephen FryHugh LaurieDeborah NortonComedians Stephen Fry and Hugh Laurie perform a variety of comedy skits and the occasional musical number.
- CreatorMark SchwahnStarsChad Michael MurrayJames LaffertyHilarie Burton MorganHalf-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.