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- DirectorDavid LynchStarsAnthony HopkinsJohn HurtAnne BancroftA Victorian surgeon rescues a heavily disfigured man who is mistreated while scraping a living as a side-show freak. Behind his monstrous façade, there is revealed a person of kindness, intelligence and sophistication.
- DirectorKaran JoharStarsShah Rukh KhanKajolSheetal MenonAn Indian Muslim man with Asperger's syndrome takes a challenge to speak to the President of the United States seriously and embarks on a cross-country journey.
- DirectorLasse HallströmStarsJohnny DeppLeonardo DiCaprioJuliette LewisA young man in a small Midwestern town struggles to care for his mentally-disabled younger brother and morbidly obese mother while attempting to pursue his own happiness.
- DirectorBarry LevinsonStarsDustin HoffmanTom CruiseValeria GolinoAfter a selfish L.A. yuppie learns his estranged father left a fortune to an autistic-savant brother in Ohio that he didn't know existed, he absconds with his brother and sets out across the country, hoping to gain a larger inheritance.
- DirectorJessie NelsonStarsSean PennMichelle PfeifferDakota FanningAn intellectually disabled man fights for custody of his 7-year-old daughter and in the process teaches his cold-hearted lawyer the value of love and family.
- DirectorStephen ChboskyStarsJacob TremblayOwen WilsonIzabela VidovicBased on the New York Times bestseller, this movie tells the incredibly inspiring and heartwarming story of August Pullman, a boy with facial differences who enters the fifth grade, attending a mainstream elementary school for the first time.
- DirectorPetter NæssStarsJosh HartnettRadha MitchellGary ColeA love story between two savants with Asperger's syndrome, a kind of autism, whose conditions sabotage their budding relationship.
- DirectorXavier DolanStarsAnne DorvalAntoine Olivier PilonSuzanne ClémentA widowed single mother, raising her violent son alone, finds new hope when a mysterious neighbor inserts herself into their household.
- DirectorAlonso MayoStarsLou Taylor PucciJayne EastwoodPam HyattSheltered by his grandparents, Luke, a young man with autism, is thrust into a world that doesn't expect anything from him. But Luke is on a quest for a job and true love. And he isn't taking no for an answer.
- DirectorMick JacksonStarsClaire DanesJulia OrmondDavid StrathairnA biopic of Temple Grandin, an autistic woman who has become one of the top scientists in the humane livestock handling industry.
- DirectorElissa DownStarsRhys WakefieldLuke FordToni ColletteAll Thomas wants is a normal adolescence but his autistic brother, Charlie, thwarts his every opportunity. Will Thomas, with the help of his girlfriend, Jackie, accept his brother?
- DirectorSimon ShoreStarsKeeley HawesBen MilesSheila HancockA true story about a couple's struggles to meet the challenges of their son's autism.
- DirectorRobert ZemeckisStarsTom HanksRobin WrightGary SiniseThe history of the United States from the 1950s to the '70s unfolds from the perspective of an Alabama man with an IQ of 75, who yearns to be reunited with his childhood sweetheart.
- DirectorPeter BogdanovichStarsCherEric StoltzSam ElliottA teenager with a massive facial skull deformity and biker gang mother attempt to live as normal a life as possible under the circumstances.
- DirectorJonathan KarshStarsSusan TomAnthony TomFaith TomDocumentary following Susan Tom of Fairfield, California and her 11 adopted special needs children.
- DirectorJim SheridanStarsDaniel Day-LewisBrenda FrickerAlison WhelanChristy Brown, born with cerebral palsy, learns to paint and write with his only controllable limb - his left foot.
- DirectorOlivier NakacheÉric ToledanoStarsFrançois CluzetOmar SyAnne Le NyAfter he becomes a quadriplegic from a paragliding accident, an aristocrat hires a young man from the projects to be his caregiver.
- DirectorLars von TrierStarsBjörkCatherine DeneuveDavid MorseAn Eastern European US immigrant with a love for musicals has to cope with the gradual loss of her vision.
- DirectorDavid FincherStarsBrad PittCate BlanchettTilda SwintonTells the story of Benjamin Button, a man who starts aging backwards with consequences.
- DirectorArthur PennStarsAnne BancroftPatty DukeVictor JoryThe story of Anne Sullivan's struggle to teach the blind and deaf Helen Keller how to communicate.
- DirectorMaciej PieprzycaStarsDawid OgrodnikDorota KolakArkadiusz JakubikThe story of a boy suffering from cerebral palsy and his troubled growing up during Poland's transition in the 1980s and 90s.
- DirectorAndy SerkisStarsAndrew GarfieldClaire FoyHugh BonnevilleThe inspiring true love story of Robin and Diana Cavendish, an adventurous couple who refuse to give up in the face of a devastating disease.
- DirectorTom HooperStarsColin FirthGeoffrey RushHelena Bonham CarterThe story of King George VI, his unexpected ascension to the throne of the British Empire in 1936, and the speech therapist who helped the unsure monarch overcome his stammer.
- DirectorMilos FormanStarsJack NicholsonLouise FletcherMichael BerrymanIn the Fall of 1963, a Korean War veteran and criminal pleads insanity and is admitted to a mental institution, where he rallies up the scared patients against the tyrannical nurse.
- DirectorJulie TaymorStarsSalma HayekAlfred MolinaGeoffrey RushA biography of artist Frida Kahlo, who channeled the pain of a crippling injury and her tempestuous marriage into her work.
- DirectorUgur YücelStarsUgur YücelBeren SaatAyça BingölAt 2 Ela lost her ability of seeing and hearing because of a severe illness. And then she became a total disappointment of her family due to her untamed behaviors. But everything changed after a teacher stepped into their lives to educate Ela while healing himself.
- DirectorJanet GrilloStarsBeth BroderickAshley RickardsAramazd StepanianThe story of Jeanne and her autistic teenage daughter, Mandy. Jeanne has cared for Mandy since the day she was born, growing closer every day to a child who is charmingly offbeat one moment and nearly impossible to manage the next.
- DirectorGren WellsStarsRobert SheehanDev PatelZoë KravitzA young man with Tourette's Syndrome embarks on a road trip with his recently-deceased mother's ashes.
- DirectorGeorge C. WolfeStarsHilary SwankEmmy RossumJosh DuhamelA drama centered on a classical pianist who has been diagnosed with ALS and the brash college student who becomes her caregiver.
- DirectorGoran PaskaljevicStarsLazar RistovskiJasna ZalicaJovana MiticA simple story of an ex-convict who comes home after 10 years, only to find two squatters in the form of a woman and her autistic daughter. Though Lazar initially plans to kick out Jasna and Jovana, he changes his mind after seeing the squalid conditions of the shelter they are to move into. It is an allegory of the Balkan wars. When first released in Serbia, it caused some public outrage because of the sharp criticism of Serbia's role in the war.
- DirectorAdam ElliotStarsToni CollettePhilip Seymour HoffmanEric BanaIn 1976 Melbourne, a lonely 8-year-old girl strikes up a correspondence with an unlikely pen pal: a severely obese 44-year-old New Yorker with Asperger's syndrome.
- DirectorLarry PeerceStarsMarilyn HassettBeau BridgesBelinda MontgomeryYoung ski champion Jill Kinmont is left paralyzed after a tragic skiing accident. Her best friend suffers the same fate after contracting polio. Jill must slowly put her life back together again with the help of those close to her.
- DirectorRichard LaGraveneseStarsHilary SwankImelda StauntonPatrick DempseyA young teacher inspires her class of at-risk students to learn tolerance, apply themselves and pursue education beyond high school.
- DirectorJohn BadhamStarsRichard DreyfussJohn CassavetesChristine LahtiKen Harrison is an artist who makes sculptures. One day he is involved in a car accident, and is paralyzed from his neck down. All he can do is talk, and he wants to die. In hospital he make friends with some of the staff, and they support him when he goes to trial to be allowed to die.
- DirectorRichard GlatzerWash WestmorelandStarsJulianne MooreAlec BaldwinKristen StewartA linguistics professor and her family find their bonds tested when she is diagnosed with Alzheimer's Disease.
- DirectorChris DowlingStarsKristoffer PolahaDavid DeSanctisMcKaley MillerA baseball player whose professional career was cut short due to his personal problems is suddenly awakened and invigorated by a young-man with Down syndrome who works at the local grocery store.
- DirectorMarcos CarnevaleStarsNorma AleandroLuis LuqueLeonor MansoAnita is a girl who suffers from Down Syndrome and lives with her mother in the Once neighborhood in Buenos Aires. On July 18, 1994, the bombing attack on the AMIA changes her life forever.
- DirectorJulian SchnabelStarsMathieu AmalricEmmanuelle SeignerMarie-Josée CrozeThe true story of Elle editor Jean-Dominique Bauby who suffers a stroke and has to live with an almost totally paralyzed body; only his left eye isn't paralyzed.
- DirectorMatt FullerAutism in Love follows the story of four adults with autism spectrum disorders as they search for and manage romantic relationships.
- DirectorScott HicksStarsGeoffrey RushArmin Mueller-StahlJustin BrainePianist David Helfgott, driven by his father and teachers, has a breakdown. Years later he returns to the piano, to popular if not critical acclaim.
- DirectorRob BurnettStarsCraig RobertsPaul RuddSelena GomezA man suffering a family loss enrolls in a class about care-giving that changes his perspective on life.
- DirectorIrwin WinklerStarsVal KilmerMira SorvinoKelly McGillisA blind man has an operation to regain his sight at the urging of his girlfriend and must deal with the changes to his life.
- DirectorThea SharrockStarsEmilia ClarkeSam ClaflinJanet McTeerA girl in a small town forms an unlikely bond with a recently-paralyzed man she's taking care of.
- DirectorRon HowardStarsRussell CroweEd HarrisJennifer ConnellyA mathematical genius, John Nash made an astonishing discovery early in his career and stood on the brink of international acclaim. But the handsome and arrogant Nash soon found himself on a harrowing journey of self-discovery.