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- A supernatural medical drama that centers on the lives of the doctors and nurses of Hope Zion Hospital.
- Big city lawyer Joanna Hanley returns to her hometown to take the case of a group of girls suffering from a mysterious illness.
- The series follows five young nurses working on the front lines of St. Mary's Hospital dedicating their lives to helping others, while figuring out how to help themselves.
- Three female homicide detectives solve crimes while also dealing with their personal lives.
- Docudrama on Jerry Greben who has worked as a stand-in in the film industry for 30 years.
- Wolf is assigned to a patient who has lost hope that she will receive a life-saving lung transplant in time; Keon confides in a former football friend about a traumatic incident; Naz is assigned as Sinead's assistant.
- Grace is forced to confront her own past trauma when she encounters a patient whose diagnosis proves to be elusive.
- Keon gets hazed by Nurse Molly, then gets off on the wrong foot with a patient in handcuffs. Wolf suddenly finds himself under serious financial pressure and considers taking desperate measures.
- When Naz realizes her patient has a more serious condition than anyone realized, Naz forms a special bond with the patient's cousin. An over-exhausted and under-slept Wolf struggles on the job and draws Damien's wrath.
- Ashley and Caro explore past relationships. Keon grapples with Molly's attempts to sideline him. Naz tries to balance her emotional connection to a patient with his medical needs. Wolf is forced to leave his comfort zone and care for a newborn baby. An after shift house party with the group allows them to bond. During the party, a guest becomes ill, it challenges keeping their work life separate from their personal time.
- Ashley receives an ultra-religious patient who is willing to put himself at peril to appease God, forcing Ashley to reconsider her own religious past. Naz supports a pregnant patient through the hardest decision of her life.
- Keon finds himself supporting his patient's fiancée when a swift recovery has an unexpected side effect. Naz treats a former Olympian whose rare condition requires creative solutions; Wolf helps a frequent flyer with hearing loss. Grace puts her job on the line when her patient collapses.
- Under pressure to steal more drugs, Wolf is forced into an ethical dilemma in which he is turned against his patient; while trying to protect her patient before a major surgery, Ash is forced to confront Sinead about her drinking problems.
- The troubled hospital has trouble-shooter Kate Faulkner in charge of the nurses. Wolf gets pulled deeper. Ashley is assigned to a difficult patient. Keon has two. Nazneen has a famous chef. Grace has bed bugs, abused woman, and a cute guy.
- Grace is tasked with making a terminal patient's last day special, despite the patient's selfish family and her own emotional response to being part of an assisted dying procedure.
- Ashley is now a patient. Grace's lawyer sister has come in for business and Matteo seems to be the target. Nazneen has a code Cheech situation. Wolf's fling with Dr. Turcotte has issues. Keon encounters his past.
- It's full moon. Grace still hates Matteo. They spot a little boy who is worried about his grandpa back home. A patient feels invincible. Another thinks that he cursed himself. Wolf is forced into a drug heist.
- Ashley is assisting a respected veteran surgeon but she spots a tremor in his hand. Grace gets involved. Wolf starts rehab. Cash-strapped Nazneen gets a clown patient. Keon's blind patient has dementia.
- A guy brings in a baby. Kate shows off her black belt skills. A bridal party has a shopping cart problem. Nazneen bought a place. Keon is troubled with his patient's broken back.
- Grace and Ashley are still at odds over the surgery, but a mass casualty event at a concert forces them to come together-in ways they couldn't have predicted. On his first day back from leave, Wolf is determined to make a clean slate.
- It's National Nurses Week. Grace is the social media subject. She thinks that Matteo had slept with her sister. Ashley has a pregnant patient. Wolf has a mute kid. Keon and Nazneen have a divorcee and her contractor.
- Assigned to the Burn Unit, Naz and Grace are pushed to their limits as Nurses - and friends - when they disagree over how to deal with a critically burned patient who's in danger of losing his will to live.
- With both patients and the whole Healthcare system on the brink of tragic events, the St Mary's nursing team must put their own struggles aside to help those with everything on the line.
- With Charlie's life hanging in the balance, Alex and Dawn go head-to-head over who gets to be his legal decision maker - but are forced to put personal matters aside when they scrub into a heart transplant surgery together. Charlie, meanwhile, is in no mood to talk to the heart donor - a deceased prisoner.
- When Hope Zion Hospital's Chief of Surgery ends up in a coma, he finds himself wandering the halls in spirit form. Stuck between worlds, he watches as his fiancée and the staff of the hospital fight to keep patients - and hope - alive.
- When Joel gets cold feet in the OR, Kinney takes him with her on a Continuing Medical Education assignment in her hometown to help clear his head. During their field trip, a woman gets pinned underneath a truck and Joel and Kinney lead the rescue effort. Meanwhile, Charlie meets a newly deceased therapist who suspects it's an emotional block that is keeping him in his coma. Encouraged by Charlie breathing on his own, Alex continues her rounds and diagnoses a fitness buff with a rare condition.
- With Charlie removed from his ventilator, all he and Alex can do is wait and ask themselves: is this really it? But when a patient comes in for a routine follow-up, her new symptoms could lead Alex and Charlie to making a discovery about Charlie's coma. Meanwhile, Joel cannot operate after breaking his hand, and Maggie and Gavin deal with the aftermath of their kiss.
- When a plane is forced to land due to a sick passenger, the patient is taken to Hope Zion where Alex performs emergency surgery and discovers that this passenger may have brought a deadly and contagious virus into the hospital.
- Alex and Shahir bring Charlie to the O.R. for a last resort procedure, but Charlie must first face his past before he can wake up. Meanwhile, Joel performs a risky surgery on a female jockey and Gavin crosses the line when he meets an Alzheimer's patient.
- After a major turn of events, Alex is faced with a monumental question: is her life now changed forever? Meanwhile, Joel is in a race against time to save a young patient from rapidly advancing flesh-eating disease.
- Alex treats a young boy with mysterious symptoms while dealing with the arrival of Charlie's ex-wife. Elsewhere in the hospital, Joel and Maggie try to help a patient who refuses life-saving treatment on religious grounds.
- Charlie returns to Hope Zion for his first shift as a doctor since waking from the coma and is surprised that he can still see the spirits of people who died at the hospital.
- After Charlie's hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.
- After six months working undercover, Andy and Nick's operation goes sideways when Nick - then Andy - go missing. Meanwhile, a random arrest at 15 Division puts Sam Swarek and the other officers in the middle of the investigation-turned-rescue-mission.
- A high profile double hand replantation becomes Alex's chance to prove to Kinney that she is still capable of being Chief Surgical Resident. In the ICU, Maggie believes a homeless man may have been misdiagnosed.
- A sleep-deprived Alex takes on a night shift in the ER where an all-star hockey enforcer may be skating full-speed towards an early death. Meanwhile, Charlie meets a suburban punk who is facing the biggest fight of his life.
- When a severely injured man under the spell of hypnosis cannot remember his identity, the hypnotist who put him under is called into the hospital - where he uses his psychic ability to connect Charlie and Alex. Meanwhile, a young woman comes into the E.R. with a neck injury, but it's Hope Zee's psych resident, Gavin who knows how to help her.
- A routine surgical procedure goes awry when Alex's patient, a soon-to-be-wed young woman, falls into a coma. While Alex struggles with a case that hits close to home, Joel treats a patient who does his own body modifications, and Charlie finds himself drawn to Alex's coma patient in the spirit world.
- Frank proposes to Noelle. Andy works a bank robbery case with Swarek on her first day back at 15. Dov attempts to help an attractive Italian women whose passport has been stolen.
- Alex learns to stand up to Charlie's ex-wife Dawn.
- While struggling under the pressure of deciding on her specialty, Alex is inspired by an immigrant doctor who needs her help to save his wife.
- The doctors are forced to deal with people from their past as Alex, Charlie, and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path.
- Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do a routine procedure.
- After a young, healthy, and hunky fireman dies suddenly at a Hope Zion Hospital fundraiser, Alex must take the stand at Hope Zion's Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie and Zack deal with a nervous aspiring nun with an ankle fracture that turns serious when they stumble upon a potentially fatal allergy. A busy Joel struggles to balance his workload as Chief with his growing commitment to Sonja, and must decide if he's ready to step up to the plate.
- When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.
- When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they're forced to use only what's around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.
- When Alex is forced to put a patient's gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane - and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who's been admitted to Hope Zion Hospital.
- With her body still in a coma, Alex shares an emotional journey with Charlie in the spirit world as he 'ghost-doctors' a brain-dead mother-to-be. Meanwhile, Joel forms a tight bond with a lively drug addict while trying to treat his necrotic leg. Hope Zion Hospital also welcomes its new OB/GYN, Dr. Sydney Katz, who throws Maggie off her game.
- Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square-off over differing treatment options when two fused-together burn victims are brought into the ER. Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.